منابع مشابه
Hooking up with Oct4.
The transcription factor Oct4 plays a central role in controlling the undifferentiated state of embryonic and induced pluripotent stem cells. Two complementary papers in this issue of Cell Stem Cell describe the extended network of proteins that interact with Oct4. Together, these studies broaden our understanding of the control of pluripotency.
متن کاملEpigenetic silencing of Oct4 by a complex containing SUV39H1 and Oct4 pseudogene lncRNA
Pseudogene-derived, long non-coding RNAs (lncRNAs) act as epigenetic regulators of gene expression. Here we present a panel of new mouse Oct4 pseudogenes and demonstrate that the X-linked Oct4 pseudogene Oct4P4 critically impacts mouse embryonic stem cells (mESCs) self-renewal. Sense Oct4P4 transcription produces a spliced, nuclear-restricted lncRNA that is efficiently upregulated during mESC d...
متن کاملPost-Translational Regulation of Oct4 Transcriptional Activity
Oct4 is a key component of the molecular circuitry which regulates embryonic stem cell proliferation and differentiation. It is essential for maintenance of undifferentiated, pluripotent cell populations, and accomplishes these tasks by binding DNA in multiple heterodimer and homodimer configurations. Very little is known about how formation of these complexes is regulated, or the mechanisms th...
متن کاملDevelopment: Sketch for a Theory of Oct4
How is it that Oct4, a transcription factor that controls pluripotency in stem cells, also controls lineage specification? A recent study investigating common Oct4 targets in vertebrate species indicates an evolutionarily conserved role in mediating cell adhesion. This finding may help decipher Oct4's versatility in governing stem cell behaviors.
متن کاملBidirectional talk between AhR and Oct4
The aryl hydrocarbon receptor (AhR) is a member of the family of basic helix-loop-helix transcription factors that is widely expressed in most differentiated mammalian cells and implicated in a variety of cellular processes, such as cell cycle progression, cell migration, carcinogenesis and immune functions. Upon the binding of its synthetic or natural ligands, the cytosolically-located AhR is ...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2004
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-04-0688